What could be other use of wheel on the mouse other than viewing web pages, it is simple scrolling up or down. Now, in Vista, it can do even more.Use it quickly to resize your desktop icons.Make them larger or smaller with a simple key press and rolling of the mouse wheel.

Use the Wheel
Left click anywhere on your Vista desktop so it becomes the focus of your mouse. While holding down the CTRL key on your keyboard, roll the wheel on your mouse forward or back to instantly make your desktop icons smaller or larger.